Posts Tagged ‘infectious disease’

July 9, 2012

Positive cultures of organ preservation fluid predict postoperative infections in solid organ transplantation recipients


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Organ preservation fluid is not routine cultured at most centers. However, there are several reports of candida transmission from organ preservation fluid. ¾In this single-center retrospective study, the authors describe the microbiology of organ preservation fluid samples for 331 organs. Preservation fluid was positive in more than 60% of cases although the majority of these […]

No Comments Posted in Transplant Infectious Disease
July 9, 2012

Outcome of HCV/HIV-Coinfected Liver Transplant Recipients: A Prospective and Multicenter Cohort Study


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The life expectancy of HIV positive persons has improved considerably in the past decade. Several countries are now performing kidney and liver transplants in HIV infected recipients. One of the leading indications for liver transplant in HIV patients is Hepatitis C. This study from Spain examines whether outcomes are similar in HCV/HIV coinfected patients as […]

No Comments Posted in Liver Transplantation, Transplant Infectious Disease
July 9, 2012

Yellow fever vaccination in organ transplanted patients: is it safe? A multicenter study


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Live virus vaccines such as yellow fever are generally contraindicated for immunosuppressed organ transplant recipients. However, transplanted persons residing in or travelling to yellow fever endemic regions are at great risk. Currently, a waiver of vaccination is given to transplant patients who wish to travel to a yellow fever endemic region. This multicenter study from […]

No Comments Posted in Transplant Infectious Disease
July 9, 2012

Risk and Prognosis of Hospitalization for Pneumonia Among Individuals With and Without Functioning Renal Transplants in Denmark: A Population-Based Study


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Pneumonia is a common problem post-transplant. The authors studied kidney transplant candidates and recipients to determine risk factors for pneumonia at the population level. Over 4000 transplant candidates and recipients in addition to over 80,000 controls were included in this study from Denmark. In transplant patients, the risk for hospitalization from pneumonia was 8-fold higher […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
July 9, 2012

Homozygosity for the toll-like receptor 2 R753Q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation


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Innate immune responses have not been well studied in the context of CMV replication. TLR2, a cell surface pattern recognition receptor, recognizes the CMV envelope glycoprotein. This study examined a large cohort of liver transplant patients that were typed for a known single nucleotide polymorphism in the TLR2 receptor. 11% of patients had 1 or […]

No Comments Posted in Liver Transplantation, Transplant Infectious Disease
July 9, 2012

Cytomegalovirus Replication Kinetics in Solid Organ Transplant Recipients Managed by Preemptive Therapy


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Many transplant centers use CMV prophylaxis in CMV mismatched patients. However, this study examined a large cohort of CMV D+/R- or R+ liver and kidney patients who were all managed with pre-emptive therapy. CMV syndrome occurred in approximately one-third of transplant patients that were D+/R- and in a greater proportion of those who had liver […]

No Comments Posted in Transplant Infectious Disease
July 9, 2012

Importance of the cytomegalovirus seropositive recipient as a contributor to disease burden after solid organ transplantation


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The incidence of cytomegalovirus (CMV) syndrome after adult solid organ transplantation continues to be a health care burden. In this retrospective analysis of solid organ transplants from 12 UK centreês, patients were followed for two years for the occurrence of CMV disease. The authors present their results comparing the probability of CMV viremia among intermediate […]

No Comments Posted in Transplant Infectious Disease
April 14, 2012

Association of Cytomegalovirus Infection and Disease With Recurrent Hepatitis C After Liver Transplantation.


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CMV infection post-transplant is responsible for direct end-organ disease but may also contribute to other infections through its immunomodulatory properties. Previous studies do not show a consistent link between CMV and recurrence of hepatitis C post-liver transplant. In this retrospective study, CMV infection was associated with an increased fibrosis and inflammation scores. This was regardless […]

No Comments Posted in Liver Transplantation, Transplant Infectious Disease
April 14, 2012

Dengue virus infection in renal allograft recipients: a case series during 2010 outbreak.


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Dengue is a mosquito-transmitted disease endemic in South-East Asia. There are very few reports of Dengue infection post-organ transplant. This report describes 8 cases of dengue viral infection in renal transplant recipients, 3 of who developed severe disease with fatal hemorrhagic shock. Transplant patients need to be aware of personal-protection measures against mosquitos when travelling […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
April 14, 2012

Chromosomally integrated human herpesvirus-6 in transplant recipients


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CIHHV-6 occurs in a small proportion of patients and presents with very high HHV-6 viral loads. It can be mistaken for active infection and unnecessarily treated. In this case series, 7 liver transplant patients with CIHHV-6 are described in addition to 14 cases already published in the literature. Although no patient had clinical symptoms related […]

No Comments Posted in Transplant Infectious Disease