Posts Tagged ‘infectious disease’

April 14, 2012

A Cluster of Pneumocystis Infections Among Renal Transplant Recipients: Molecular Evidence of Colonized Patients as Potential Infectious Sources of Pneumocystis jirovecii.


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Kidney transplant recipients are usually receive prophylaxis for Pneumocystis infections for 6-12 months post-transplant. Although infections are generally uncommon, several outbreaks in transplant patients have been reported in the past two decades. In this study from France, 18 kidney transplant patients developed Pneumocystis infection. These patients were compared to control patients with Pneumocystis pneumonia. Molecular […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
April 14, 2012

Can Immune Cell Function Assay Identify Patients at Risk of Infection or Rejection? A Meta-Analysis


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An assay to quantify how immunosuppressed an individual is would be a great asset in clinical practice. The Cylex ImmuKnow assay measures ATP-release from CD4+ T cells and is used in some transplant centers to guide management of immunosuppression. In this study, the authors performed a meta-analysis to determine whether this assay could identify the […]

No Comments Posted in Transplant Infectious Disease
April 14, 2012

Multicenter study of histoplasmosis and blastomycosis after solid organ transplantation


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Endemic fungi can cause severe infections in solid organ transplant recipients. This retrospective review from 3 transplant centres reviews the presentation and management of 30 solid organ transplant recipients with histoplasmosis or blastomycosis between 1998 and 2008, noting an incidence of infection of 0.5%. The majority of the patients were renal transplants. Time of onset […]

No Comments Posted in Lung Transplantation
April 14, 2012

Clinical and radiological features of respiratory syncytial virus in solid organ transplant recipients: a single-center experience


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Respiratory syncytial virus (RSV) infection is well known to cause serious pulmonary infections in hematopoietic stem cell transplant recipients, but the effect of this virus in solid organ transplant recipients is less understood. This retrospective review identified 24 patients within 3 years who developed RSV infection, 50% of who were solid organ transplant recipients (5 […]

No Comments Posted in Lung Transplantation
February 23, 2012

Primary and Reactivated HHV8 Infection and Disease After Liver Transplantation: A Prospective Study.


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HHV8 is a herpesvirus and a causative agent of Kaposi’s sarcoma and Castleman’s disease.  As with other latent herpesviruses, it can be transmitted via organ transplantation from a seropositive donor to a seronegative recipient.  Italy has a high seroprevalence of HHV8 (~18%).  In this study, the authors reviewed HHV8 infections in the first year post-liver […]

No Comments Posted in Transplant Infectious Disease
February 23, 2012

Influenza Vaccination in the Organ Transplant Recipient: Review and Summary Recommendations


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Annual influenza vaccination is recommended for organ transplant patients although the different types of influenza vaccines and timing of vaccination can be a source of confusion for the provider.  This review summarizes the current state of knowledge for annual influenza vaccination the organ transplant recipient.  It discusses the various studies done in the transplant population […]

No Comments Posted in Transplant Infectious Disease
February 23, 2012

Outcome of treated and untreated asymptomatic bacteriuria in renal transplant recipients.


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Asymptomatic bacteriuria in post-kidney transplant recipients is very common and may or may not be treated.  The need for therapy is guided by a number of factors including the presence of pyuria, the time post-transplant, immunosuppression, and renal function.  However, therapy is commonly instituted and very often leads to antimicrobial resistance.  Whether treatment of asymptomatic […]

No Comments Posted in Transplant Infectious Disease
February 23, 2012

Clinical utility of molecular surveillance for cytomegalovirus after antiviral prophylaxis in high-risk solid organ transplant recipients.


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Late CMV disease is common after the discontinuation of prophylaxis especially in the high-risk CMV D+/R- group.  Transplant centers take various approaches to detect CMV disease and these include prolonging prophylaxis, doing weekly CMV viral load monitoring, or observing for symptoms.  In this single-center review, 71 high-risk patients received 3 months of antiviral prophylaxis followed […]

No Comments Posted in Transplant Infectious Disease
February 23, 2012

Virologic and Immunologic Monitoring of Cytomegalovirus to Guide Preemptive Therapy in Solid-Organ Transplantation


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There is increasing literature on immunologic monitoring for cytomegalovirus (CMV) post-transplant in order to guide antiviral therapy.  Assays used for immune monitoring include the Quantiferon-CMV, ELISpot, and flow cytometry-based quantitation of CMV-specific T-cells.  In this study, 134 SOT patients had immunologic monitoring by flow cytometry as well as CMV viral loads.  At 1 year after […]

No Comments Posted in Transplant Infectious Disease
February 23, 2012

Risk Factors, Clinical Features, and Outcomes of Toxoplasmosis in Solid-Organ Transplant Recipients: A Matched Case-Control Study.


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Toxoplasmosis is a relatively uncommon infectious complication after transplant.  Seropositive heart transplant recipients or heart transplant recipients who receive toxoplasmosis seropositive hearts generally receive lifelong prophylaxis.  A review of SOTs done in Spain identified 22 cases of toxoplasmosis.  Although the majority of these were heart transplant recipients, kidney and liver transplant patients also developed the […]

No Comments Posted in Transplant Infectious Disease