Posts Tagged ‘infectious diseases’

June 21, 2013

Special Issue: The American Society of Transplantation Infectious Diseases Guidelines 3rd Edition


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This supplement to the American Journal of Transplantation is dedicated to transplant infectious diseases. The articles in the supplement are guidelines for various pathogens and infectious syndromes that affect transplant recipients. This is the 3rd edition of the guidelines and updates the previous edition published in 2009. Three new chapters were added to this edition: […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation, Transplant Infectious Disease
October 30, 2012

Monitoring of Immunoglobulin Levels Identifies Kidney Transplant Recipients at High Risk of Infection


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Infections post-transplant are common, but it is difficult to predict which patients are most at risk. Hypogammaglobulinemia is a known risk factor for infection. In this prospective, single-center observational study, low immunoglobulin levels were common post-transplant, and correlated with an increased risk of infection. This study raises the question of whether such monitoring should become […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
October 1, 2011

Impact of norovirus/sapovirus-related diarrhea in renal transplant recipients hospitalized for diarrhea


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Chronic diarrhea is a clinical dilemma in transplantation and often no specific cause is found.  Norovirus/sapovirus are enteric viruses that are increasingly recognized as a cause of chronic diarrhea in transplant patients.  In this retrospective study, kidney transplant patients hospitalized for diarrhea were studied.  Of the 41 patients with chronic diarrhea, about half were screened […]

No Comments Posted in Transplant Infectious Disease
October 1, 2011

Impact of Hepatitis C Virus Infection on the Risk of Infectious Complications After Kidney Transplantation: Data From the RESITRA/REIPI Cohort


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RESITRA/REIPI is a Spanish Network for Research in Transplantation that has previously conducted robust studies of post-transplant infections.  In this prospective analysis, the authors compared infectious complications between 1302 kidney transplant patients that were HCV positive (n=105) vs. HCV negative.  There was no difference in the overall incidence of infections; however, HCV positive patients had […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
October 1, 2011

A Prospective Longitudinal Study Evaluating the Usefulness of a T-Cell-Based Assay for Latent Tuberculosis Infection in Kidney Transplant Recipients


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Screening for tuberculosis (TB) prior to transplant is recommended prior to transplantation with either the tuberculin skin test or an interferon-gamma release assay (IGRA) such as the T-SPOT.TB ELISPOT assay.  However, it is unclear which test would better predict post-transplant TB.  In this study, the authors enrolled 312 patients admitted for kidney transplant; all patients […]

No Comments Posted in Renal Transplantation, Transplant Infectious Disease
October 1, 2011

Association of Cytomegalovirus Infection and Disease With Death and Graft Loss After Liver Transplant in High-Risk Recipients


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In the transplant literature, data associating CMV with rejection and mortality are conflicting.  In this retrospective cohort of 227 CMV D+/R- liver transplant recipients, the authors used a combined endpoint of graft loss or death.  CMV infection and disease was reported in 40% and 19% of patients respectively within one year of transplant; this is […]

No Comments Posted in Liver Transplantation, Transplant Infectious Disease
July 4, 2011

Effect of Kidney Transplantation on Outcomes among Patients with Hepatitis C


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Patients with hepatitis C need to be carefully evaluated before renal transplantation, due to concerns that they liver disease may progress more rapidly after transplant and lead to liver failure. In this single-center study of hepatitis C-infected patients, liver biopsy data both before transplant, on the wait list and after transplant were available. Kidney transplantation […]

No Comments Posted in Renal Transplantation
June 18, 2011

A 2010 working formulation for the standardization of definitions of infections in cardiothoracic transplant recipients


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There is variability in how bacterial, viral, and fungal infections are defined after cardiothoracic transplantation, leading to variation in reported incidences of disease and epidemiology of infections.  This consensus report attempts to standardize definitions of common and uncommon infections by combining clinical features, radiology, and microbiology.  These definitions can be used for future descriptive or […]

No Comments Posted in Cardiac Transplantation, Lung Transplantation, Transplant Infectious Disease
June 18, 2011

Antibody Response After a Single Dose of an AS03-Adjuvanted Split-Virion Influenza A (H1N1) Vaccine in Heart Transplant Recipients


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Pandemic influenza caused a wide spectrum of disease in organ transplant recipients.    Monovalent adjuvanted H1N1 vaccine became available in Canada and Europe whereas a nonadjuvanted formulation was available in the U.S.  This European study showed that only one-third of the vaccinated cohort had seroprotective titers to vaccine.  These results are similar to other studies presented […]

No Comments Posted in Transplant Infectious Disease
June 18, 2011

Factors associated with chronic hepatitis in patients with hepatitis e virus infection who have received solid organ transplants.


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Hepatitis E is thought to be a self-limiting illness. However, in the past two years, there are increasing reports of chronic hepatitis with this virus.  In this multicenter review of Hepatitis E, compared to patients who resolved infection, those who progressed to chronic hepatitis tended to have lower platelet counts and were on tacrolimus (as […]

No Comments Posted in Transplant Infectious Disease