Posts Tagged ‘IVUS’

June 21, 2013

Differential Effect of Everolimus on Progression of Early and Late Cardiac Allograft Vasculopathy in Current Clinical Practice.


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CAV remains the leading cause of long-term death in heart transplant recipients. This retrospective analysis of prospectively collected data (IVUS) demonstrated everolimus independently reduced the odds for early CAV (0.14 [0.01_0.77]; p 0.02) but it did not appear to influence late CAV progression. High dose statin use was favorably associated with a reduction in both […]

No Comments Posted in Cardiac Transplantation
April 1, 2013

Donor-Specific Antibodies to Class II Antigens Are Associated With Accelerated Cardiac Allograft Vasculopathy: A Three-Dimensional Volumetric Intravascular Ultrasound Study.


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This preliminary study from Mayo clinic demonstrated that cardiac transplant patients with preformed class II DSA may be at increased risk for accelerated graft vasculopathy on consecutive 3D IVUS. Although this technology may not be available at all centers, this sstudy provides further weight to the potential clinical impact of class II DSA.

No Comments Posted in Cardiac Transplantation
October 30, 2012

Virtual Histology Assessment of Cardiac Allograft Vasculopathy Following Introduction of Everolimus-Results of a Multicenter Trial


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This randomized controlled study reviews the changes in plaque morphology in maintenance heart transplant recipients on everolimus and reduced calcineurin inhibitor vs standard therapy. Conversion to everolimus and reduced calcineurin inhibitor was associated with a significant increase in calcified and necrotic intimal components and is more prominent in patients with a longer time since HTx. […]

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November 18, 2011

Safety and efficacy of early aggressive versus cholesterol-driven lipid-lowering strategies in heart transplantation: A pilot, randomized, intravascular ultrasound study


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The safety and efficacy of pravastatin, simvastatin and atorvastatin in heart transplant recipients have been tested in several single-center studies. This study demonstrated that a titrated-dosing approach of fluvastatin is as effective as a maximal early dose in achieving target LDL levels at 1year post transplant. The maximal-dosing approach seems to provide additional benefit by […]

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