Posts Tagged ‘kidney transplantation’

January 28, 2013

Living kidney donors and their family caregivers: developing an evidence-based educational and social support website.


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Living kidney donor candidates and their family caregivers participating in the Living Donor Information Network for Caregiving (LINC) have access to a variety of online informational resources and a social support discussion forum throughout their living kidney donation experience. Strategies in the development and implementation of an online information and social-support resource are presented.

No Comments Posted in Renal Transplantation
January 28, 2013

Living kidney donors and their family caregivers: developing an evidence-based educational and social support website.


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Living kidney donor candidates and their family caregivers participating in the Living Donor Information Network for Caregiving (LINC) have access to a variety of online informational resources and a social support discussion forum throughout their living kidney donation experience. Strategies in the development and implementation of an online information and social-support resource are presented.

No Comments Posted in Renal Transplantation
October 30, 2012

Monitoring of Immunoglobulin Levels Identifies Kidney Transplant Recipients at High Risk of Infection


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Up to one-third of transplant recipients can develop hypogammaglobulinemia. However, it is controversial whether the presence of hypogammaglobulinemia leads to an increased risk of infections. Further, many transplant centers do not do routine monitoring for this. The authors of this paper prospectively monitored 226 kidney transplant patients at 0, 1, 6 months post-transplant. At one […]

No Comments Posted in Transplant Infectious Disease
October 30, 2012

Monitoring of Immunoglobulin Levels Identifies Kidney Transplant Recipients at High Risk of Infection


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Up to one-third of transplant recipients can develop hypogammaglobulinemia. However, it is controversial whether the presence of hypogammaglobulinemia leads to an increased risk of infections. Further, many transplant centers do not do routine monitoring for this. The authors of this paper prospectively monitored 226 kidney transplant patients at 0, 1, 6 months post-transplant. At one […]

No Comments Posted in Transplant Infectious Disease
May 23, 2012

Durability of Antibody Removal Following Proteasome Inhibitor-Based Therapy


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Experience with proteasome inhibitors (PI) for treating antibody-mediated rejection (ABMR) and HLA antibody removal is increasing. However, the durability of the effects PI on HLA antibody removal is unknown. This study examines this question from a unique point of view due to the use of the PI bortezomib as either a combination therapy or a […]

No Comments Posted in Renal Transplantation
February 23, 2012

Prevention and treatment of alloantibody-mediated kidney rejection


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The problem of antibody-mediated rejection (ABMR) due to donor specific HLA antibodies continues to challenge transplant programs as we struggle to find effective treatments. This very detailed review carefully outlines the various treatment options attempted in dealing with ABMR or desensitization including some not so common protocols such as immunoadsorption. Furthermore, insightful views regarding organ […]

No Comments Posted in Renal Transplantation
February 23, 2012

Terminal complement inhibition decreases antibody-mediated rejection in sensitized renal transplant recipients


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Antibody-mediated rejection (ABMR)in the presence of high levels of donor-specific antibodies (DSA) likely involves complement activation as part of the mechanism of graft damage. This study examined the efficacy of inhibiting complement activation by neutralizing C5 with a humanized anti-C5 antibody; eculizumab. The effect of anti-C5 treatment was assessed in 26 highly sensitized recipients of […]

No Comments Posted in Renal Transplantation