TransplantNow The Ultimate Guide to Clinical Transplant Research

Liver transplants rarely experience antibody-mediated rejection, and it has been suggested that a liver transplant can protect the kidney if a simultaneous transplant is performed. In this single-center study, patients who received a simultaneous liver-kidney transplant had a higher risk of acute rejection, but similar renal function and patient and graft survival, whether or not […]

This paper reviews the outcomes documented in the UNOS database for recipients of simulataneous thoracic and abdominal transplants. An interesting ethical discussion concludes the article.

The identification of the psychological issues that impair the quality of life and the adherence to treatment in transplant candidates are important. This study evaluated the presence of symptoms of depression and the quality of life of liver transplant candidates.One hundred liver transplant candidates underwent a psychological analysis the Short Form-36 (SF-36) Quality of Life […]

The identification of the psychological issues that impair the quality of life and the adherence to treatment in transplant candidates are important. This study evaluated the presence of symptoms of depression and the quality of life of liver transplant candidates.One hundred liver transplant candidates underwent a psychological analysis the Short Form-36 (SF-36) Quality of Life […]

A contemporary and Canadian perspective is presented on the outcomes following extended use donor criteria for solid organ transplant recipients. This Quebec based study analyzes outcomes in nonrenal organ groups.

Chronic kidney disease is a significant complication after liver transplantation. A common strategy is to add mycophenolic acid (MPA) in order to reduce or eliminate calcineurin inhibitors (CnI). Although this is a common practice, the authors were only able to find 8 randomized controlled trials assessing its effects. Use of MPA does improve renal function, […]

There is a lack of objective diagnostics test to confirm drug-induced liver injury. In this single-center study, the authors applied a specific criteria to identify the prevalence, clinical features and outcomes of drug-induced liver injury in a population of liver transplant recipients. The suspicion of drug-induced liver injury should be considered when unexplained allograft dysfunction […]

Post transplant inmunosuppression with calcineurin inhibitors (CNIs) is associated with renal dysfunction with an estimated rate of advanced CKD of 20% at 5 years. Everolimus is an mTOR inhibitors without the nephrotoxicity of CNIs. In this multicenter, prospective study, the authors evaluate the feasibility and effects of everolimus started at 30 days post liver transplant. […]

Hepatocellular carcinoma (HCC) has become one of the main indications for liver transplantation. With time, it appears that patients with HCC have easier access to transplantation than non-HCC patients due to the exception points they receive. The authors used a comparative risk model assessment of HCC vs non-HCC on the waiting list to look at […]

Left lobe living donor liver transplant (LL LDLT) has been associated with inferior graft survival due to smaller grafts. However, balancing the safety of donor and recipient is an integral part of LDLT. Several centers continue to use LL LDLT. In this aricle, the authors report a large scale study comparing outcomes of LL vs […]