Posts Tagged ‘liver transplant’

July 9, 2012

Homozygosity for the toll-like receptor 2 R753Q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

Innate immune responses have not been well studied in the context of CMV replication. TLR2, a cell surface pattern recognition receptor, recognizes the CMV envelope glycoprotein. This study examined a large cohort of liver transplant patients that were typed for a known single nucleotide polymorphism in the TLR2 receptor. 11% of patients had 1 or […]

No Comments Posted in Liver Transplantation, Transplant Infectious Disease
April 14, 2012

Association of Cytomegalovirus Infection and Disease With Recurrent Hepatitis C After Liver Transplantation.


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

CMV infection post-transplant is responsible for direct end-organ disease but may also contribute to other infections through its immunomodulatory properties. Previous studies do not show a consistent link between CMV and recurrence of hepatitis C post-liver transplant. In this retrospective study, CMV infection was associated with an increased fibrosis and inflammation scores. This was regardless […]

No Comments Posted in Liver Transplantation, Transplant Infectious Disease
April 14, 2012

Chromosomally integrated human herpesvirus-6 in transplant recipients


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

CIHHV-6 occurs in a small proportion of patients and presents with very high HHV-6 viral loads. It can be mistaken for active infection and unnecessarily treated. In this case series, 7 liver transplant patients with CIHHV-6 are described in addition to 14 cases already published in the literature. Although no patient had clinical symptoms related […]

No Comments Posted in Transplant Infectious Disease
February 23, 2012

Characterization and outcomes of young infants with acute liver failure


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

Acute liver failure in children (PALF) is a dramatic and sometimes fatal clinical syndrome in which previously healthy children rapidly lose hepatic function and become critically ill within days to weeks, and decision-making to predict the natural history is complex.  The causes of PALF are age-dependent, with young infants presenting particularly unique diagnostic considerations, with […]

No Comments Posted in Liver Transplantation
February 23, 2012

Critical review of controversial issues in the management of advanced pediatric liver tumours


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

Hepatoblastoma and hepatocellular carcinoma are the most common primary hepatic tumors in children.  To date, treatment is not standardized, and outcomes from large patient cohorts are not well documented.  The management of children with locally advanced, unresectable disease or those with extra-hepatic distant metastases is often complex and challenging for multidisciplinary teams comprised of pediatric […]

No Comments Posted in Liver Transplantation
February 23, 2012

Association between donor-specific antibodies and acute rejection and resolution in small bowel and multivisceral transplantation.


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

Antibody mediated rejection (AMR) is a well described phenomenon in kidney and heart transplant but its presence and impact on intestinal transplantation is unclear. AMR might contribute to the severity and relatively high rate of steroid resistant acute rejection in intestinal transplantation. This prospective study measured and correlated donor specific antibodies (DSA) levels to episodes […]

No Comments Posted in Liver Transplantation
February 23, 2012

The impact of MELD/PELD revisions on the mortality of liver-intestine transplantation candidates


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

Patients listed for liver-intestine transplant experience higher mortality while waiting for an organ compared to patients listed for liver transplant only. As a result UNOS implemented a new policy in 2005 and revised it again in 2007, in which adult and pediatric patients waiting for intestine-liver transplant are granted extra MELD and PELD points to […]

No Comments Posted in Liver Transplantation
February 23, 2012

Primary and Reactivated HHV8 Infection and Disease After Liver Transplantation: A Prospective Study.


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

HHV8 is a herpesvirus and a causative agent of Kaposi’s sarcoma and Castleman’s disease.  As with other latent herpesviruses, it can be transmitted via organ transplantation from a seropositive donor to a seronegative recipient.  Italy has a high seroprevalence of HHV8 (~18%).  In this study, the authors reviewed HHV8 infections in the first year post-liver […]

No Comments Posted in Transplant Infectious Disease
December 19, 2011

Psychological Factors Influencing Donors Decision-Making Pattern in Living-Donor Liver Transplantation


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

It has been purported that post transplant psychological function of living-liver donors is affected by the process of which their decision to donate was made. This study investigated 165 living-donor candidates using standardized psychological testing and semi-structured interviews, and compared results among the groups classified by type of individual and family decision-making process utilized to […]

No Comments Posted in Liver Transplantation
December 19, 2011

Hepatic Steatosis at 1 Year is an Additional Predictor of Subsequent Fibrosis Severity in Liver Transplant Recipients with Recurrent Hepatitis C Virus


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

Recurrence of HCV post liver transplantation is universal, and clinically significant recurrence can have a major impact on both patient and graft survival. Prediction of patients that will go on to significant recurrence allow for both close follow up and consideration for anti-viral therapy. The present study shows that steatosis in the early post liver […]

No Comments Posted in Liver Transplantation