Posts Tagged ‘lung transplant’

December 19, 2011

BODE index and quality of life in advanced chronic obstructive pulmonary disease before and after lung transplantation


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The BODE index is widely used to predict risk of death in COPD, as well as in the referral and listing of patients with COPD for lung transplantation.  This cohort study examined the association of BODE index with health-related quality of life in advanced COPD.  For patients in the study who received lung transplantations, the […]

No Comments Posted in Lung Transplantation
December 19, 2011

Survival benefit of lung transplantation in individuals with severe α1-anti-trypsin deficiency (PiZZ) and emphysema


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This retrospective case-control study assessed survival of patients with α1-anti-trypsin deficiency PiZZ and severe emphysema in Sweden between 1990 and 2010, comparing survival of those who underwent lung transplantation to those who were treated with usual medical care.  The transplanted group had a median survival of 11 years, as compared to median survival of 5 […]

No Comments Posted in Lung Transplantation
November 18, 2011

Persistence of Influenza Vaccine-Induced Antibodies in Lung Transplant Patients Between Seasons


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Immunization recommendations advise against immunizing too early before influenza seasons starts for concern of waning vaccine-specific antibody before the end of the season.  This 5-year study of influenza antibodies in lung transplant recipients measured the influenza antibody concentrations before annual immunizations in transplant recipients and healthy controls, finding that seroprotective influenza antibody concentrations are maintained […]

No Comments Posted in Lung Transplantation
November 18, 2011

Adherence to Immunosuppression in Adult Lung Transplant Recipients: Prevalence and Risk Factors


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Adherence to medications has not been well studied in lung transplant recipients.  Using a Medication Event Monitoring System, tacrolimus intake was prospectively monitored in 91 lung transplant recipients for a median of 95 days.  Medication adherence was 92.3%.  14% of patients had one or two drug holidays.  Non-adherent patients tended to be younger and with […]

No Comments Posted in Lung Transplantation
November 18, 2011

Timing of Basiliximab Induction and Development of Acute Rejection in Lung Transplant Patients


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Basiliximab is a monoclonal interleukin-2 receptor antagonist commonly used for induction immunosuppression in lung transplantation.  This single centre retrospective review of 119 patients transplanted between 1994 and 2009 examined the impact of the timing of basiliximab dosing on the frequency and severity of acute rejection, the development of BOS, and overall survival.  Pre-implantation administration of […]

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November 18, 2011

The Impact of Pretransplant Mechanical Ventilation on Short- and Long-Term Survival After Lung Transplantation


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Mechanical ventilation remains a strong relative contraindication to lung transplant in most centres.  Patients requiring ongoing mechanical ventilation prior to lung transplant are likely to receive a high Lung Allocation Score to reflect the higher urgency and worse expected outcome of lung transplant.  Analyzing adult lung transplants in the United States from 2005-2010 (LAS era) […]

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November 18, 2011

Spectrum of Cancer Risk Among US Solid Organ Transplant Recipients


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Malignancy is a well-recognized complication of organ transplantation. Most studies have focused on renal transplant recipients. This study uses US registry data to examine the risk of cancer among recipients of kidney, liver, lung, and heart transplants. While the risk of cancer was increased in all groups of patients, there were variations in cancer risk […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
October 1, 2011

Donor quality of life in living-donor lobar lung transplantation


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The quality of life (QOL) of 42 living lobar lung donors was investigated in a cross sectional study using the 36-item Short Form (SF-36) Health Survey to evaluate physical and mental health outcome of donors after transplant. Donors were of mean age 42 years. Results found that overall physical and mental health scores of donors […]

No Comments Posted in Lung Transplantation
October 1, 2011

The spectrum of nonadherence with medication in heart, liver, and lung transplant patients assessed in various ways


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In order to ascertain methodological gaps in assessing adherence in the literature this prospective study of adult organ transplant recipients compared 79 heart, 55 liver, and 104 lung recipients . Non-adherence was measured using self-report, collateral report, blood assays, electronic monitoring, and their combinations. In the overall sample, depending on the method used, Non-adherence ranged […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation
October 1, 2011

Psychiatric issues in pediatric organ transplantation


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This issue is special edition of Pediatric Clinics of North America that delves into the interface between children’s mental health and transplantation. Dr. Stuber provides an extensive review of the latest knowledge on psychosocial and psychiatric aspects related to pediatric solid organ transplantation, covering the spectrum from pre-transplant assessment to long term post transplantation. Issues […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation