Posts Tagged ‘lung transplantation’

June 21, 2013

Pathologic findings in lung allografts with anti-HLA antibodies


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Antibody-mediated rejection is a well recognized cause of accelerated allograft dysfunction in heart and kidney transplantation in the setting of de novo donor specific antibodies (DSA). Development of de novo DSA in lung transplant recipients has been linked with early development of bronchiolitis obliterans syndrome (BOS), although the role of antibody-mediated rejection in BOS is […]

No Comments Posted in Lung Transplantation
April 1, 2013

Pre-transplant malignancy: an analysis of outcomes after thoracic organ transplantation


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Using the UNOS database, this retrospective study compared survival post lung-transplantation or orthotopic heart transplantation in patients with pre-transplant malignancy (PTM) to a matched cohort without PTM. The incidence of PTM in lung transplants was 5.4% and in orthotopic heart transplants was 5.6%. No significant difference was noted in survival at 30-days, 1-year, and 5-years […]

No Comments Posted in Cardiac Transplantation, Lung Transplantation
April 1, 2013

Decline in 25% to 75% forced expiratory flow as an early predictor of chronic airway rejection in pediatric lung transplant recipients


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Early identification of bronchiolitis obliterans by non-invasive measures is desirable, which lead to the definition of bronchiolitis obliterans syndrome by decline in FEV1. This study hypothesized that a decline in FEF25-75 should occur before a decline in FEV1, allowing earlier diagnosis of bronchiolitis obliterans. Retrospective review of 31 pediatric lung transplantation recipients at a single […]

No Comments Posted in Lung Transplantation
April 1, 2013

Significance of and risk factors for the development of central airway stenosis after lung transplantation


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The incidence and outcomes related to post-lung transplant central airway stenosis (CAS) vary in the literature. This study aimed to identify the incidence of CAS in a large cohort of lung transplant recipients at a single centre and study the association with development of bronchiolitis obliterans syndrome (BOS) and survival. Of 467 transplanted patients, 13% […]

No Comments Posted in Lung Transplantation
April 1, 2013

Body mass index and its effect on outcome in children after lung transplantation


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With higher rates of malnutrition at the time of lung transplantation compared to adult patients, the effect of body mass index (BMI) on transplant outcome in pediatric patients is unknown. Using the International Society for Heart and Lung Transplantation Registry on Pediatric Lung Transplantation, this retrospective study classified pediatric lung recipients according to BMI and […]

No Comments Posted in Lung Transplantation
January 28, 2013

Outcomes and temporal trends among high-risk patients after lung transplantation in the United States


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In recent years, more lung transplantation centres have performed lung transplants in high risk patients, including patients with high lung allocation (LAS) scores, requiring mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) support pre-transplant. This review of the UNOS database identified that patients bridged to lung transplant with mechanical ventilation or ECMO had significantly worse short-term […]

No Comments Posted in Lung Transplantation
January 28, 2013

The effect of center volume on the incidence of postoperative complications and their impact on survival after lung transplantation


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Post operative complications and survival after lung transplantation between 1999 and 2009 was reviewed using the UNOS database, to compare outcomes in centres performing a high volume of transplants to centres performing low volumes. The incidence of postoperative complications was similar in both groups, however having a complication in a low volume center was a […]

No Comments Posted in Lung Transplantation
January 28, 2013

Increased incidence of cutaneous squamous cell carcinoma in lung transplant recipients taking long-term voriconazole


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Voriconazole is commonly prescribed for treatment of fungal infections in lung transplant recipients. Typically patients are treated for several weeks with this medication. This retrospective study of 120 lung transplant recipients compared the incidence of squamous cell carcinoma in patients with and without voriconazole use. Squamous cell carcinomas (SCC) developed in 39.5% of patients who […]

No Comments Posted in Lung Transplantation, Transplant Infectious Disease
January 28, 2013

Outcomes and temporal trends among high-risk patients after lung transplantation in the United States


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In recent years, more lung transplantation centres have performed lung transplants in high risk patients, including patients with high lung allocation (LAS) scores, requiring mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) support pre-transplant. This review of the UNOS database identified that patients bridged to lung transplant with mechanical ventilation or ECMO had significantly worse short-term […]

No Comments Posted in Lung Transplantation
January 28, 2013

The effect of center volume on the incidence of postoperative complications and their impact on survival after lung transplantation

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Post operative complications and survival after lung transplantation between 1999 and 2009 was reviewed using the UNOS database, to compare outcomes in centres performing a high volume of transplants to centres performing low volumes. The incidence of postoperative complications was similar in both groups, however having a complication in a low volume center was a […]

No Comments Posted in Lung Transplantation