Posts Tagged ‘mechanical circulatory support’

September 10, 2013

Should Eligibility for Heart Transplantation Be a Requirement for Left Ventricular Assist Device Use? Recommendations Based on a Systematic Review


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This Canadian group has generated the first systematic review of the clinical and economic effects of continuous-flow LVADs in Bridge to Transplant (BTT) and Destination Therapy (DT) patients. They conclude that evidence is sufficient to support LVAD use, regardless of transplantation eligibility status, as long as patients are carefully selected and program infrastructure and budget […]

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July 11, 2013

HeartWare ventricular assist system for bridge to transplant: Combined results of the bridge to transplant and continued access protocol trial.


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The pivotal ADVANCE Clinical Trial was a multicenter clinical trial to evaluate the HeartWare HVAD System for BTT in patients with advanced heart failure in the United States. This publication reports the analysis of combined data from the 140 BTT patients plus 192 patients from the continued access protocol (CAP) who were monitored to outcome […]

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June 21, 2013

Time course of acquired von Willebrand disease associated with two types of continuous-flow left ventricular assist devices: HeartMate II and CircuLite Synergy Pocket Micro-pump


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The risk of bleeding complications including gastrointestinal bleeding are well documented in the VAD population. In this prospective study, acquired von Willebrand disease was confirmed to occur immediately after the implantation of both types of mechanical circulatory support and persisted up to 12 months. This phenomenon was also demonstrated in the partial support device. A […]

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June 21, 2013

A Prospective, Multicenter Study of Ventricular Assist Device Infections


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This prospective study demonstrated that the incidence of ventricular assist device related infection continues to burden approximately 20% of implanted patients in the era of smaller continuous flow devices. There was an associated increase in one year mortality.

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June 21, 2013

Clinical outcomes after ventricular assist device implantation in adults with complex congenital heart disease.


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This single center case series from the Texas Heart Institute describes the clinical challanges and outcomes of 6 patients with complex CHD who underwent VAD implantation with a variety of devices. A future article (epub) is pending in the same journal (JHLT) which may provide further insight into this challenging patient population: Heart transplantation for […]

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April 1, 2013

OPTN/SRTR 2011 Annual Data Report: heart.


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This annual report from the Organ Procurement and Transplantation Network provides an American update with temporal trends in cardiac transplant activity.

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April 1, 2013

The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: Executive summary.


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The Executive summary is provided. This is a comprehensive review of the currently recommended interdisciplinary management considerations in mechanical circulatory support patients.

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April 1, 2013

Fifth INTERMACS annual report: Risk factor analysis from more than 6,000 mechanical circulatory support patients.


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The 5th annual report of the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) summarizes and analyzes the first 6 years of patient and data collection. The current analysis includes more than 6000 patients and updated risk factors for continuous flow pumps. Among continuous flow pumps, actuarial survival is 80% at 1 year and 70% […]

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January 28, 2013

Statement Regarding the Pre and Post Market Assessment of Durable, Implantable Ventricular Assist Devices in the United States: Executive Summary: Endorsed by The Society of Thoracic Surgeons, American Association for Thoracic Surgery, American Heart Association, Heart Failure Society of America, International Society for Heart and Lung Transplantation, and the Interagency Registry of Mechanically Assisted Circulatory Support.


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A panel of experts convened to discuss topics relevant to promoting an environment of safe and effective introduction of new technologies for mechanical cirulatory support. The focus of this Statement Paper includes : (1) innovative clinical trial designs; (2) the need for a new encompassing indication for therapy to facilitate device evaluation and reduce disparities […]

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January 28, 2013

Morbidity and Mortality in Heart Transplant Candidates Supported with Mechanical Circulatory Support. Is Reappraisal of the Current UNOS Thoracic Organ Allocation Policy Justified?


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Within the cardiac transplant community there has been much discussion regarding the evolution in technology of mechanical circulatory support and the impact on organ allocation. This article published in Circulation suggests transplant candidates supported with contemporary continuous flow LVADs have favorable waiting list outcomes. In contrast outcomes worsen significantly once a serious LVAD-related complication occurs. […]

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