Posts Tagged ‘meta-analysis’

June 21, 2013

Controlled-Dose Versus Fixed-Dose Mycophenolate Mofetil for Kidney Transplant Recipients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials


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There have been several trials evaluating a strategy of adjusting mycophenolic acid dose early post-transplant based on pharmacokinetic studies early post-transplant as opposed to prescribing a fixed dose to all patients. This meta-analysis of available trials showed no reduction in acute rejection or graft loss with such a practice. There were also no differences in […]

No Comments Posted in Renal Transplantation
October 30, 2012

Calcineurin Inhibitor Sparing With Mycophenolate Mofetil in Liver Transplantion: A Systematic Review of Randomized Controlled Trials


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Chronic kidney disease is a significant complication after liver transplantation. A common strategy is to add mycophenolic acid (MPA) in order to reduce or eliminate calcineurin inhibitors (CnI). Although this is a common practice, the authors were only able to find 8 randomized controlled trials assessing its effects. Use of MPA does improve renal function, […]

No Comments Posted in Liver Transplantation, Renal Transplantation
April 14, 2012

Preservation Solutions for Static Cold Storage of Kidney Allografts: A Systematic Review and Meta-Analysis


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Optimal outcomes for kidney transplants require excellent preservation of the kidney between the time of procurement and implantation. These authors performed a meta-analysis of studies comparing different preservation solutions in use today. While the number of available studies was small, Eurocollins solution was associated with a higher risk of delayed graft failure than UW, HTK, […]

No Comments Posted in Renal Transplantation
April 14, 2012

Can Immune Cell Function Assay Identify Patients at Risk of Infection or Rejection? A Meta-Analysis


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An assay to quantify how immunosuppressed an individual is would be a great asset in clinical practice. The Cylex ImmuKnow assay measures ATP-release from CD4+ T cells and is used in some transplant centers to guide management of immunosuppression. In this study, the authors performed a meta-analysis to determine whether this assay could identify the […]

No Comments Posted in Transplant Infectious Disease
December 19, 2011

Meta-Analysis of Calcineurin-Inhibitor-Sparing Regimens in Kidney Transplantation


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This is a meta-analysis of papers using a variety of approaches to reduce the toxicity of calcineurin inhibitors (CnI) in renal transplantation. Papers include a variety of approaches, such as CnI minimization, delayed introduction and avoidance. All strategies showed improvements in graft function. However, while CnI minimization or use of newer agents such as belatacept […]

No Comments Posted in Renal Transplantation