Posts Tagged ‘mTOR inhibitors’

June 21, 2013

Differential Effect of Everolimus on Progression of Early and Late Cardiac Allograft Vasculopathy in Current Clinical Practice.


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CAV remains the leading cause of long-term death in heart transplant recipients. This retrospective analysis of prospectively collected data (IVUS) demonstrated everolimus independently reduced the odds for early CAV (0.14 [0.01_0.77]; p 0.02) but it did not appear to influence late CAV progression. High dose statin use was favorably associated with a reduction in both […]

No Comments Posted in Cardiac Transplantation
November 18, 2011

Limiting Hepatitis C Virus Progression in Liver Transplant Recipients Using Sirolimus-Based Immunosuppression


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Hepatitis C recurrence following liver transplantation is universal, and it is one of the main reasons for inferior outcomes in this population. Sirolimus, which has antifibrotic properties, reduces progression of liver fibrosis in animal models. In this single-centre, retrospective study, liver transplant recipients initially treated with sirolimus showed less progression of fibrosis on surveillance biopsies […]

No Comments Posted in Liver Transplantation