Posts Tagged ‘mycophenolic acid’

April 1, 2013

Does reduction in mycophenolic acid dose compromise efficacy regardless of tacrolimus exposure level? An analysis of prospective data from the Mycophenolic Renal Transplant (MORE) Registry


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Post-transplant, mycophenolic acid (MPA) dose is frequently reduced because of side effects or toxicity. However, overall MPA levels are higher in patients on tacrolimus as opposed to cyclosporine. In this prospective study of patients who were also on tacrolimus, MPA dose reduction or discontinuation was associated with a higher risk of subsequent acute rejection. The […]

No Comments Posted in Pancreas Transplantation, Renal Transplantation
August 14, 2011

Improved Rejection Prophylaxis With an Initially Intensified Dosing Regimen of Enteric-Coated Mycophenolate Sodium in De Novo Renal Transplant Recipients


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Previous studies have defined a therapeutic area under the curve for mycophenolic acid (MPA) in the early post-transplant period, although the majority of centers do not perform routine MPA monitoring. This paper presents results of a randomized controlled trial comparing an initial higher dose of MPA to standard dosing in patients treated with steroids, cyclosporine […]

No Comments Posted in Renal Transplantation