Posts Tagged ‘nephrotoxicity’

April 14, 2012

Cyclosporine lowering with everolimus versus mycophenolate mofetil in heart transplant recipients: Long-term follow-up of the SHIRAKISS randomized, prospective study.


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This publication reveals long-term follow-up of 34 patients initially randomized to a study exploring two different cyclosporine-lowering approaches in reducing the progression of renal dysfunction in heart transplant recipients.  Cyclosporine trough levels remained stable in both arms and were significantly lower in the everolimus arm at all time-points. Proteinuria increased significantly during the first 12 […]

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April 14, 2012

PRKCB is associated with calcineurin inhibitor-induced renal dysfunction in heart transplant recipients.


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This Canadian study further expands the knowledge on potential biomarkers of calcineurin inhibitor induced nephrotoxicity and may play a future role in developing personalized immunosuppression profiles for individual heart transplant recipients.

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