Posts Tagged ‘organ donation’

October 7, 2013

Single-lung transplantation can be performed with acceptable outcomes using selected donors with heavy smoking history


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A shortage of organ donors can prompts centres to use suboptimal donors. This review of the UNOS database determined that adult single-lung transplantations performed with lungs from heavy smoking donors (>20 pack years) have worse outcomes when compared to transplants from standard donors, including longer length of stay and lower peak FEV1 after transplant. Higher […]

No Comments Posted in Lung Transplantation
July 9, 2012

Arguments against promoting organ transplants from brain-dead donors, and views of contemporary Japanese on life and death


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A revision of Japan’s Organ Transplant Law in 2009 led to an ethical debate on the differences in definitions of death, age requirements for donors, requirements for brain-death determination and organ extraction, and the appropriateness of priority transplants for relatives. Many hoped the revised law would permit transplants in Japan according to global standards. However, […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
April 14, 2012

Should we allow organ donation euthanasia? Alternatives for maximizing the number and quality of organs for transplantation


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The authors promote a concept that is initially shocking- that organ donation euthanasia would be a rational improvement over current practice regarding withdrawal of life support. They argue that there are several untested methods of increasing organ donation, including euthanasia, and that patients should be given the choice of whether and how they would like […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
October 1, 2011

Medium-term outcome after lung transplantation is comparable between brain-dead and cardiac-dead donors


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Donation after cardiac death (DCD) is being utilized to extend the donor organ shortage in lung transplantation.  This retrospective study compared the actuarial survival rates at 6 months, 1 year, and 3 years between a cohort of 21 DCD lung transplant recipients and donation after brain death lung transplant recipients, finding no significant differences.  Freedom […]

No Comments Posted in Lung Transplantation
August 14, 2011

Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation


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Low usage of lungs from multi-organ donors has prompted researchers to pursue innovative strategies for allowing transplantation of non-optimal lungs.  One such innovation is ex vivo lung perfusion with the use of acellular normothermic perfusate after retrieval, allowing assessment of lung viability prior to implantation.  This prospective, nonrandomized clinical trial examined primary graft dysfunction in […]

No Comments Posted in Lung Transplantation
August 14, 2011

Derivation of the Uncontrolled Donation after Circulatory Determination of Death Protocol for New York City.


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This article and its accompanying editorial examine the UDCDD protocol in New York City, in which people who die from cardiac arrest out of hospital can be used as organ donors.  The article explains how the protocol was developed, and the involvement of government officials, content experts (including ethicists) and the public in the process. […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
June 18, 2011

Recommendations for the Use of Extended Criteria Donors in Lung Transplantation


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Organ shortages have prompted many centers to use non-optimal donor lungs for transplantation.  This review summarizes the relevant literature regarding the use of extended criteria lung donors and the expected impact of these marginal lungs on recipient outcomes.

No Comments Posted in Lung Transplantation