Posts Tagged ‘panel reactive antibodies’

November 18, 2011

Effect of sensitization in US heart transplant recipients bridged with a ventricular assist device: Update in a modern cohort


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This study reviewed outcomes of 1544 UNOS based patients bridged to transplant with the HeartMate II or Thoratec XVE devices based on distribution of percentage panel reactive antibody levels.  Contrary to some previously published single center studies and smaller cohorts, highly sensitized patients bridged to transplant experienced excellent survival outcomes after orthotopic heart transplantation.

No Comments Posted in Cardiac Transplantation
November 18, 2011

Reduction of alloantibodies via proteosome inhibition in cardiac transplantation


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The approach to desensitization varies between cardiac transplant centers.  This pilot study by Kobashigawa et al, explores a new approach in desensitization attempts in patients refractory to an IVIg/rituximab combination therapy.  Bortezomib successfully reduced cPRA in the majority of patients with an acknowledged increase risk of infection.

No Comments Posted in Cardiac Transplantation