Posts Tagged ‘pediatric’

April 1, 2013

OPTN/SRTR 2011 Annual Data Report: heart.


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This annual report from the Organ Procurement and Transplantation Network provides an American update with temporal trends in cardiac transplant activity.

No Comments Posted in Cardiac Transplantation
April 14, 2012

Pediatric health-related quality of life after intestinal transplantation


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As the number of short term survivors of pediatric intestine transplantation increases, a better understanding of the unique aspects of health related quality of life (HRQOL) after intestine transplantation can improve the care of the patient and his family. This single center, prospective analysis of HRQOL of pediatric intestine transplant recipients and their parents compared […]

No Comments Posted in Intestinal Transplantation
February 23, 2012

Characterization and outcomes of young infants with acute liver failure


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Acute liver failure in children (PALF) is a dramatic and sometimes fatal clinical syndrome in which previously healthy children rapidly lose hepatic function and become critically ill within days to weeks, and decision-making to predict the natural history is complex.  The causes of PALF are age-dependent, with young infants presenting particularly unique diagnostic considerations, with […]

No Comments Posted in Liver Transplantation
February 23, 2012

Critical review of controversial issues in the management of advanced pediatric liver tumours


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Hepatoblastoma and hepatocellular carcinoma are the most common primary hepatic tumors in children.  To date, treatment is not standardized, and outcomes from large patient cohorts are not well documented.  The management of children with locally advanced, unresectable disease or those with extra-hepatic distant metastases is often complex and challenging for multidisciplinary teams comprised of pediatric […]

No Comments Posted in Liver Transplantation
February 23, 2012

Association between donor-specific antibodies and acute rejection and resolution in small bowel and multivisceral transplantation.


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Antibody mediated rejection (AMR) is a well described phenomenon in kidney and heart transplant but its presence and impact on intestinal transplantation is unclear. AMR might contribute to the severity and relatively high rate of steroid resistant acute rejection in intestinal transplantation. This prospective study measured and correlated donor specific antibodies (DSA) levels to episodes […]

No Comments Posted in Liver Transplantation
February 23, 2012

The impact of MELD/PELD revisions on the mortality of liver-intestine transplantation candidates


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Patients listed for liver-intestine transplant experience higher mortality while waiting for an organ compared to patients listed for liver transplant only. As a result UNOS implemented a new policy in 2005 and revised it again in 2007, in which adult and pediatric patients waiting for intestine-liver transplant are granted extra MELD and PELD points to […]

No Comments Posted in Liver Transplantation
February 23, 2012

The influence of low donor age, living related donation and pre-emptive transplantation on end-organ damage based on arterial hypertension after paediatric kidney transplantation


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This retrospective study evaluates the impact of donor age, donor source and pre-emptive transplantation on the development of post-transplant hypertension in pediatric kidney transplant recipients.

No Comments Posted in Renal Transplantation
February 23, 2012

Association between age and graft failure rates in young kidney transplant recipients.


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Renal transplantation during adolescence is a well-established risk factor for long-term graft loss.  Using the USRDS database, this retrospective cohort study analyzes the graft outcomes of over 18,000 young kidney transplant recipients (<21 yrs of age) and identifies age-specific death-censored graft failure rates and hazard ratios of graft loss, compared to an older cohort of […]

No Comments Posted in Renal Transplantation
February 23, 2012

Calcineurin inhibitor minimization using sirolimus leads to improved renal function in pediatric heart transplant recipients.


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The use of calcineurin inhibitors (CNI) as part of the immunosuppressive regime following transplantation is associated with an increased risk of renal dysfunction. There are a limited number of reports on the role CNI minimization for renal recovery following pediatric heart transplant. These authors describe their experience with sirolimus and low dose cyclosporine in those […]

No Comments Posted in Cardiac Transplantation
February 23, 2012

Red blood cell transfusions in children awaiting heart transplantation


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Although not studied in the pediatric population, red blood cell (RBC) transfusions may be beneficial in children awaiting transplantation. However, the use of RBC transfusions has been associated with increasing the risk of allosensitization. This retrospective, single center study examined the role of both RBC transfusions and erythropoietin in hospitalized children awaiting transplant who where […]

No Comments Posted in Cardiac Transplantation