Posts Tagged ‘pediatric’

February 23, 2012

Trends in Wait-List Mortality in Children Listed for Heart Transplantation in the United States: Era Effect Across Racial/Ethnic Groups


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This study utilized the Organ Procurement and Transplant Network (OPTN) database for all children <18 years old listed for heart or multivisceral transplant, between 1989-2009 and examined the effect of era and race on waitlist mortality.  Their analysis showed that the overall waitlist mortality has decreased across the eras after adjustment for patient related factors. […]

No Comments Posted in Cardiac Transplantation
February 23, 2012

Invasive fungal infections in pediatric heart transplant recipients: Incidence, risk factors, and outcomes


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There are limited studies examining either the incidence or risk factors for invasive fungal infections following pediatric heart transplant. This multi-institutional study from the Pediatric Heart Transplant Study group represents the largest analysis of invasive fungal infections following pediatric heart transplantation.  Invasive fungal infections accounted for a small percentage (6.8%) of the overall infections. These […]

No Comments Posted in Cardiac Transplantation
February 23, 2012

What is high risk? Redefining elevated pulmonary vascular resistance index in pediatric heart transplantation


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The risk of right heart failure early post transplant has lead some centers to avoid cardiac transplant in children with a pulmonary vascular resistance index (PVRi) >6 Wu x m2. However, this number is not universally agreed upon.  This retrospective, single center review of 158 cardiomyopathy patients transplanted between 1984-2010 examined the role of elevated PVRi […]

No Comments Posted in Cardiac Transplantation
October 1, 2011

Medical adherence in pediatric organ transplantation: what are the next steps?


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There is a growing body of research on the high rates and negative consequences of non-adherence after transplantation. This article reviews the current literature on medication and regimen adherence after transplantation with the goal of identifying gaps in the literature, as well as suggestions for future research. The authors highlight the current knowledge but emphasize […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
October 1, 2011

Psychiatric issues in pediatric organ transplantation


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This issue is special edition of Pediatric Clinics of North America that delves into the interface between children’s mental health and transplantation. Dr. Stuber provides an extensive review of the latest knowledge on psychosocial and psychiatric aspects related to pediatric solid organ transplantation, covering the spectrum from pre-transplant assessment to long term post transplantation. Issues […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation
October 1, 2011

Doppler tissue imaging in children following cardiac transplantation: A comparison to catheter-derived hemodynamics


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In this study, the authors continue the quest to identify echocardiography-derived indices sensitive enough to diagnose or predict rejection, or further down the road, maybe even early coronary allograft vasculopathy.  Though the primary aim was not proven (the ratio of early mitral inflow velocity compared to annular tissue velocity, septal E:Ea; did not correlate with […]

No Comments Posted in Cardiac Transplantation
October 1, 2011

The impact of heart failure severity at time of listing for cardiac transplantation on survival in pediatric cardiomyopathy


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In this unique study, a dataset merging patients within both the Pediatric Cardiomyopathy Registry and the Pediatric Heart Transplant Study is analyzed to address the question of the survival benefit of transplantation for children with cardiomyopathies based on severity of heart failure.  Given the ongoing shortage of organ donors, especially within the pediatric age group, […]

No Comments Posted in Cardiac Transplantation
August 14, 2011

Organ donation from children: time for legal, ethical and cultural change.


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This article examines the child as an organ donor, both while alive and after death, from a European perspective.  Differences between the European and North American systems (e.g. allowable definition of brain death in infants, donation after cardiac death and allowing capable adolescents to be living donors) are discussed, and a re-examination of the laws […]

No Comments Posted in Cardiac Transplantation, Liver Transplantation, Lung Transplantation, Renal Transplantation