Posts Tagged ‘pediatrics’

April 14, 2012

Should we retransplant a patient who is non-adherent? A literature review and critical reflection.


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Graft loss due to medication non-adherence remains a significant obstacle to optimal long-term outcomes for the transplant community. The decision to retransplant a patient who has been non-adherent to their medication regimen is one of ethical debate, yet little evidence exists to guide health professionals in this process. This manuscript sought to fill this gap […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Renal Transplantation, Transplant Infectious Disease
February 23, 2012

Allosensitization and outcomes in pediatric heart transplantation


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Allosensitization of pediatric heart transplant candidates continues to be a problem with uncertainty on the best clinical approach to manage these patients. Using data from the Pediatric Heart Transplant Study, the current study examined >3000 patients listed for heart transplantation of which 2237 were transplanted with available panel reactive antibody (PRA) data. The outcomes for […]

No Comments Posted in Cardiac Transplantation
December 19, 2011

Monitoring Nonadherence and Acute Rejection with Variation in Blood Immunosuppressant Levels in Pediatric Renal Transplantation.


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Acute rejection related to non-adherence to treatment after transplant remains a barrier to optimal outcomes. This study builds on prior literature which asserts that monitoring variation of drug levels is a viable method to reliably detect nonadherence and prevent rejection in pediatric patients. Investigators followed 46 pediatric renal transplant recipients and measured tacrolimus and mycophenolic […]

No Comments Posted in Renal Transplantation
October 1, 2011

Liver Transplantation for Classical Maple Syrup Urine Disease: Long-Term Follow-Up in 37 Patients and Comparative United Network for Organ Sharing Experience


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Maple syrup urine disease (MSUD; OMIM 248600) is an autosomal recessive disorder characterized by impaired activity of the branched-chain alpha-keto acid dehydrogenase complex.  The resulting accumulated branched-chain L-amino acids (BCAAs) and alpha-keto acids exert neurotoxic effects.  The clinical course is typically punctuated by episodes of ketoacidosis, each potentially life-threatening.   Medical therapy is limited to dietary […]

No Comments Posted in Liver Transplantation
October 1, 2011

Characterization and Outcomes of Young Infants with Acute Liver Failure


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Acute liver failure (ALF) in infants and children is a devastating condition.  This study aimed to characterize infants aged <=90 days enrolled in an international, multicenter, prospective registry of children aged <18 years with acute liver failure before May 18, 2009.  A total of 148 infants were identified, with median age of 18 days.  Common […]

No Comments Posted in Liver Transplantation
October 1, 2011

A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation


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The goal of this study was to identify significant, independent factors predicting 6 month patient and graft survival after pediatric liver transplantation, utilizing data from the Studies of Pediatric Liver Transplantation (SPLIT) registry.  Established in 1995, this international multi-center database currently houses data on more than 4,000 children who have undergone liver transplantation in the […]

No Comments Posted in Liver Transplantation