Posts Tagged ‘pharmacokinetics’

June 21, 2013

Controlled-Dose Versus Fixed-Dose Mycophenolate Mofetil for Kidney Transplant Recipients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials


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There have been several trials evaluating a strategy of adjusting mycophenolic acid dose early post-transplant based on pharmacokinetic studies early post-transplant as opposed to prescribing a fixed dose to all patients. This meta-analysis of available trials showed no reduction in acute rejection or graft loss with such a practice. There were also no differences in […]

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July 9, 2012

Leflunomide Efficacy and Pharmacodynamics for the Treatment of BK Viral Infection


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Leflunomide has been proposed as a replacement for mycophenolic acid in patients with BK nephropathy, as it has immunosuppressive properties and activity against BK in vitro. In this retrospective study, there was no correlation between leflunomide metabolite levels and clearance of BK viremia. This study highlights the need for well-designed randomized controlled trials to determine […]

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