Posts Tagged ‘proteasome inhibition’

February 23, 2012

Reduction of alloantibodies via proteosome inhibition in cardiac transplantation


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HLA antibodies produced by plasma cells are a major barrier for patients awaiting heart transplantation due to increased wait list time, increased risk of rejection post-transplant, and decreased survival. Proteasome inhibition using bortezomib can lead to plasma cell apoptosis and potentially decrease antibody production. As already shown in renal transplants where bortezomib decreases antibody production […]

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