Posts Tagged ‘proteinuria’

November 28, 2013

Planned Randomized Conversion From Tacrolimus to Sirolimus-Based Immunosuppressive Regimen in De Novo Kidney Transplant Recipients


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While sirolimus has some features that make it an attractive immunosuppressant, it is less effective at preventing acute rejection than calcineurin inhibitors (CnI). An alternate strategy is to use CnI early post-transplant and then switch to sirolimus at some point post-transplant. In this randomized controlled trial, patients with good graft function and no other contraindications […]

No Comments Posted in Renal Transplantation
September 1, 2013

Podocyte Effacement Closely Links to suPAR Levels at Time of Posttransplantation Focal Segmental Glomerulosclerosis Occurrence and Improves With Therapy


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Serum soluble urokinase-type plasminogen activator receptor (suPAR) has been put forth as the a candidate for the elusive “FSGS” factor that may lead to aggressive and early recurrence post-transplant. This study of patients with recurrent FSGS post-transplant found higher suPAR levels in patients with more extensive podocyte damage on renal biopsy. However, this study is […]

No Comments Posted in Renal Transplantation
October 1, 2011

Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis


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Recurrence of focal segmental glomerulosclerosis (FSGS) post-transplant can be dramatic and lead to graft loss. Several years ago, a “permeability factor” was discovered that seemed to cause recurrence, and could be removed by plasma exchange. However, until now, the nature of this factor has been unknown. In this set of experiments, the authors show that […]

No Comments Posted in Renal Transplantation
August 14, 2011

Monitoring and Managing Graft Health in the Kidney Transplant Recipient


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This is an introduction to a collection of articles focusing on care of the healthy renal transplant recipient after the early post-transplant period. The articles in this section focus on the components of a routine clinic visit, the metabolic syndrome, proteinuria and anemia. The focus is on recognizing and managing those factors that play an […]

No Comments Posted in Renal Transplantation
July 4, 2011

Living Donor Age and Kidney Transplant Outcomes


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This large single-center study examined the effect of living-donor age on the outcomes of renal transplantation. Living-donor kidneys from older donors were associated with a higher incidence of post-transplant proteinuria. The relationship between living-donor age and long-term graft survival was also more significant for younger, but not older recipients.

No Comments Posted in Renal Transplantation