Posts Tagged ‘randomized controlled trial’

October 30, 2012

Calcineurin Inhibitor Sparing With Mycophenolate Mofetil in Liver Transplantion: A Systematic Review of Randomized Controlled Trials


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Chronic kidney disease is a significant complication after liver transplantation. A common strategy is to add mycophenolic acid (MPA) in order to reduce or eliminate calcineurin inhibitors (CnI). Although this is a common practice, the authors were only able to find 8 randomized controlled trials assessing its effects. Use of MPA does improve renal function, […]

No Comments Posted in Liver Transplantation, Renal Transplantation
August 17, 2012

Sirolimus and Secondary Skin-Cancer Prevention in Kidney Transplantation


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This randomized controlled trial assessed whether sirolimus would prevent further skin cancers in patients who have had a first squamous-cell skin cancer post-renal transplant. Patients were either continued on their calcineurin inhibitor or were switched to sirolimus. Freedom from a second skin cancer was longer with sirolimus. Switching to sirolimus earlier after a fist skin […]

No Comments Posted in Renal Transplantation
July 9, 2012

Randomized Phase 2b Trial of Tofacitinib (CP-690,550) in De Novo Kidney Transplant Patients: Efficacy, Renal Function and Safety at 1 Year


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Tofacitinib is the first in a new class of immunosuppressive agents that inhibit janus kinase, an important transcription factor. This randomized-controlled trial compared tofacitinib to cyclosporine in renal transplant patients. Tofacitinib showed lower rates of acute rejection and chronic changes on biopsy, with better renal function compared to a cyclosporine-based regimen. On the other hand, […]

No Comments Posted in Renal Transplantation
July 9, 2012

Randomized Trial of Short-Course High-Dose Erythropoietin in Donation After Cardiac Death Kidney Transplant Recipients


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Donation after cardiac death (DCD) donors have become an important source of organs, but the rates of delayed graft function (DGF) remains high. Erythropoietin may protect against schema-reperfusion injury. In this randomized controlled trial, erythropoietin or placebo was given to recipients of DCD kidneys. There was no difference in DGF rates, acute rejection, or renal […]

No Comments Posted in Renal Transplantation
June 14, 2011

Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the folic acid for vascular outcome reduction in transplantation trial


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The FAVORIT study is the largest randomized controlled trial ever conducted in renal transplantation. It examined whether lowering homocysteine levels using folic acid, vitamin B6 and vitamin B12 would reduce cardiovascular events in a group of stable renal transplant patients. Although homocysteine levels were lowered, there was no difference in cardiovascular events, death or graft […]

No Comments Posted in Renal Transplantation