Posts Tagged ‘Rejection’

October 6, 2013

The Registry of the International Society for Heart and Lung Transplantation: Thirtieth Official Adult Heart Transplant Report—2013; Focus Theme: Age


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The 30th adult heart transplant ISHLT report is based on data submitted on 110,486 heart transplants in recipients of all ages (including 99,008 adults) by 407 centers worldwide since 1982 through June 30, 2012, with follow-up until June 30, 2012.

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September 2, 2013

Influence of Race/Ethnic Differences in Pre-Transplant Panel Reactive Antibody on Outcomes in Heart Transplant Recipients.


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Racial and ethnic differences in long-term survival after HT are well recognized. This US study demonstrated that after adjusting for BMI, blood type, sensitization, presence of VAD at transplant, and region, both Black and Hispanic race/ethnicity ( β=0.046, p

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June 21, 2013

Everolimus Versus Mycophenolate Mofetil in Heart Transplantation: A Randomized, Multicenter Trial.


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This multicenter, randomized controlled trial assessed the efficacy, safety and incidence of CAV in de novo heart transplant patients receiving everolimus at two doses (1.5 mg/day or 3.0 mg/day in divided doses) with reduced-dose cyclosporine versus MMF with full-dose cyclosporine. The high dose everolimus group was terminated due to increased mortality. The lower dose everolimus […]

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June 21, 2013

Correlation of circulating donor-specific anti-HLA antibodies and presence of C4d in endomyocardial biopsy with heart allograft outcomes: A single-center, retrospective study.


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Approximately 10 – 20% of heart transplant recipients will develop AMR. Standardized nomenclature has improved the diagnosis. This single center study revisits the risks of Class I and II DSA to C4D +IF and graft failure. C4d staining correlated better with graft failure in patients with DSA to only Class I or DSA to both […]

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May 23, 2012

Prope tolerance to heart allografts in mice associated with persistence of donor interleukin-10-transduced stem cells


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Rejection, which requires life long immunosuppressive agents and the associated morbidity/side-effects, remains the main limiting factor in longevity following heart transplantation. �Prope� or almost tolerance is a state of recipient graft acceptance allowing for low, non-toxic immunosuppression dosages that may be eventually discontinued. This study explored the effects of donor interleukin-10-transduced stem cells in two […]

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July 4, 2011

The ISHLT working formulation for pathologic diagnosis of antibody-mediated rejection in heart transplantation: Evolution and current status (2005-2011)


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Antibody mediated rejection (AMR) was a focus of the ISHLT 2011 Annual Conference. This Consensus paper reviews several technical issues, discusses nomenclature and proposes a new grading system to allow for standardization in the classification and diagnosis of AMR.

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July 4, 2011

A prospective, randomized trial of single-drug versus dual-drug immunosuppression in heart transplantation: the tacrolimus in combination, tacrolimus alone compared (TICTAC) trial


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The TICTAC trial is the first prospective test of single-drug versus dual-drug maintenance immunosuppression in heart transplantation. Rapid steroid tapering was successful in all study patients. Three-year survival and low rates of allograft rejection and vasculopathy were observed in both arms (either TAC monotherapy or TAC/MMF), supporting the efficacy of either regimen along with a […]

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