Posts Tagged ‘renal transplant’

August 31, 2013

Higher Risk of Kidney Graft Failure in the Presence of Anti-Angiotensin II Type-1 Receptor Antibodies


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While HLA antibodies are a well-recognized risk factor for graft loss, the role of non-HLA antibodies is less clear. Antibodies to angiotensin II type I receptor has been previously reported in patients with failing grafts. In this study, patients who developed anti-AT I receptor antibodies had a higher risk of graft failure over and above […]

No Comments Posted in Renal Transplantation, Uncategorized
August 30, 2013

Improving Outcomes of Renal Transplant Recipients With Behavioral Adherence Contracts: A Randomized Controlled Trial


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Non-adherence is a well-recognized risk factor for adverse events post-transplant, but there have been few interventions aimed at improving adherence. In this randomized controlled trial, regular interaction with a pharmacist and a contract laying out behaviours required of the patient improved adherence, as measured by medication refills. It also resulted in fewer hospitalization.

No Comments Posted in Renal Transplantation, Uncategorized
August 2, 2013

Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts


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The gold standard fro diagnosing acute rejection remains biopsy. A non-invasive test that could reliably diagnose rejection would be an important step forward. In this study, a set of three different RNA molecules in the urine of renal transplant recipients showed a high degree of sensitivity for acute cellular rejection, and distinguished it from antibody-mediated […]

No Comments Posted in Renal Transplantation
June 21, 2013

Phospholipase A2 Receptor (PLA2R) Staining Is Useful in the Determination of De Novo Versus Recurrent Membranous Glomerulopathy


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The phospholipiase A2 receptor (PLA2R) has been identified as an important target in most cases of native membranous nephropathy. Distinguishing between post-transplant recurrent membranous nephropathy and de novo disease is important, In this paper, staining of renal transplant biopsies for PLA2R was found in cases with recurrent, but not de novo disease. This shows that […]

No Comments Posted in Renal Transplantation
June 21, 2013

Oral Paricalcitol Reduces the Prevalence of Posttransplant Hyperparathyroidism: Results of an Open Label Randomized Trial


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Bone disease and secondary hyperparathyroidism are common following renal transplantation. This open-label randomized controlled trial compared the calcitriol analog paricalcitol to placebo, with a primary endpoint of hyperparathyroidism at one year post-transplant. There was less hyperparathyroidism in the paricalcitol-treated group. However, there was no difference in bone density between groups. Also, these patients were not […]

No Comments Posted in Renal Transplantation
June 21, 2013

Controlled-Dose Versus Fixed-Dose Mycophenolate Mofetil for Kidney Transplant Recipients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials


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There have been several trials evaluating a strategy of adjusting mycophenolic acid dose early post-transplant based on pharmacokinetic studies early post-transplant as opposed to prescribing a fixed dose to all patients. This meta-analysis of available trials showed no reduction in acute rejection or graft loss with such a practice. There were also no differences in […]

No Comments Posted in Renal Transplantation
April 1, 2013

Health-Related Quality of Life and Long-Term Survival and Graft Failure in Kidney Transplantation: A 12-Year Follow-Up Study


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Long-term survival for kidney transplant continues to show variability. This study examined whether health-related quality of life (HRQOL) predicts long-term mortality in kidney transplantation after adjustment for known risk factors. A cohort of 347 kidney transplant recipients was followed up for 12 years after enrolment. They completed measures of HRQOL and medical records were reviewed […]

No Comments Posted in Renal Transplantation
April 1, 2013

Pregnancy in Renal Transplant Recipients: A UK National Cohort Study


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Pregnancy after renal transplantation is not uncommon, but there are few large studies to assess the risks. This studied captured all pregnancies among renal transplant recipients in the UK between 2007 and 2009 and compared to matched controls. Rates of pre-eclampsia, preterm delivery and small gestational size were higher than controls, but most pregnancies were […]

No Comments Posted in Renal Transplantation
January 28, 2013

Enteric Oxalate Nephropathy in the Renal Allograft: An Underrecognized Complication of Bariatric Surgery


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Bariatric surgery is an established treatment for obesity, but one recognized complication is hyperoxaluria due to the shortened small intestine. This article presents two cases of patients with a past history of bypass surgery who developed allograft dysfunction due to oxalate deposition in the graft. Early recognition, including monitoring of oxalate levels, may prevent graft […]

No Comments Posted in Renal Transplantation
January 28, 2013

Angiotensin II Blockade in Kidney Transplant Recipients


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ACE-inhibitors and ARBs are a mainstay of treatment for patients with glomerular renal disease or proteinuria. In this randomized controlled trial, patients receiving a renal transplant were randomized to losartan or placebo. There was no difference in the primary endpoint, which was a composite of doubling of interstitial fibrosis on renal biopsy at five years […]

No Comments Posted in Renal Transplantation