Posts Tagged ‘sirolimus’

November 28, 2013

Planned Randomized Conversion From Tacrolimus to Sirolimus-Based Immunosuppressive Regimen in De Novo Kidney Transplant Recipients


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While sirolimus has some features that make it an attractive immunosuppressant, it is less effective at preventing acute rejection than calcineurin inhibitors (CnI). An alternate strategy is to use CnI early post-transplant and then switch to sirolimus at some point post-transplant. In this randomized controlled trial, patients with good graft function and no other contraindications […]

No Comments Posted in Renal Transplantation
August 17, 2012

Sirolimus and Secondary Skin-Cancer Prevention in Kidney Transplantation


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This randomized controlled trial assessed whether sirolimus would prevent further skin cancers in patients who have had a first squamous-cell skin cancer post-renal transplant. Patients were either continued on their calcineurin inhibitor or were switched to sirolimus. Freedom from a second skin cancer was longer with sirolimus. Switching to sirolimus earlier after a fist skin […]

No Comments Posted in Renal Transplantation
April 14, 2012

Randomized Controlled Trial of Sirolimus for Renal Transplant Recipients at High Risk for Nonmelanoma Skin Cancer

Several randomized controlled trials have shown lower rates of non-melanoma skin cancer among patients who receive sirolimus from the time of transplant. This study randomized previously transplanted patients who had previously had at least one skin cancer to either continue on their usual immunosuppression or change their calcineurin inhibitor to sirolimus. There were fewer new […]

No Comments Posted in Renal Transplantation
February 23, 2012

Calcineurin inhibitor minimization using sirolimus leads to improved renal function in pediatric heart transplant recipients.


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The use of calcineurin inhibitors (CNI) as part of the immunosuppressive regime following transplantation is associated with an increased risk of renal dysfunction. There are a limited number of reports on the role CNI minimization for renal recovery following pediatric heart transplant. These authors describe their experience with sirolimus and low dose cyclosporine in those […]

No Comments Posted in Cardiac Transplantation
December 19, 2011

Meta-Analysis of Calcineurin-Inhibitor-Sparing Regimens in Kidney Transplantation


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This is a meta-analysis of papers using a variety of approaches to reduce the toxicity of calcineurin inhibitors (CnI) in renal transplantation. Papers include a variety of approaches, such as CnI minimization, delayed introduction and avoidance. All strategies showed improvements in graft function. However, while CnI minimization or use of newer agents such as belatacept […]

No Comments Posted in Renal Transplantation
November 18, 2011

Limiting Hepatitis C Virus Progression in Liver Transplant Recipients Using Sirolimus-Based Immunosuppression


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Hepatitis C recurrence following liver transplantation is universal, and it is one of the main reasons for inferior outcomes in this population. Sirolimus, which has antifibrotic properties, reduces progression of liver fibrosis in animal models. In this single-centre, retrospective study, liver transplant recipients initially treated with sirolimus showed less progression of fibrosis on surveillance biopsies […]

No Comments Posted in Liver Transplantation
August 14, 2011

Increased Risk of Venous Thromboembolism with a Sirolimus-Based Immunosuppression Regimen in Lung Transplantation


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Sirolimus, an anti-proliferative agent, is increasingly used for maintenance immunosuppression in lung transplantation.  A number of adverse effects have been associated with this medication, including serious effects such as poor wound healing and anastomotic dehiscence.  This study identified another potentially serious adverse effect.  The incidence of venous thromboembolism in lung transplant recipients using sirolimus, tacrolimus, […]

No Comments Posted in Lung Transplantation
August 14, 2011

The ORION Study: Comparison of Two Sirolimus-Based Regimens versus Tacrolimus and Mycophenolate Mofetil in Renal Allograft Recipients


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This randomized controlled trial in de novo renal transplant recipients compared a standard immunosuppressive protocol of daclizumab induction, tacrolimus, mycophenolate mofetil (MMF) and steroids, to either: sirolimus and tacrolimus, with tacrolimus discontinued by four months post-transplant, or sirolimus and MMF. The sirolimus and MMF group was stopped early due to a high incidence of acute […]

No Comments Posted in Renal Transplantation