Posts Tagged ‘Tacrolimus’

November 28, 2013

Planned Randomized Conversion From Tacrolimus to Sirolimus-Based Immunosuppressive Regimen in De Novo Kidney Transplant Recipients


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While sirolimus has some features that make it an attractive immunosuppressant, it is less effective at preventing acute rejection than calcineurin inhibitors (CnI). An alternate strategy is to use CnI early post-transplant and then switch to sirolimus at some point post-transplant. In this randomized controlled trial, patients with good graft function and no other contraindications […]

No Comments Posted in Renal Transplantation
January 28, 2013

Conversion From Twice-Daily Tacrolimus to Once-Daily Extended Release Tacrolimus (LCPT): The Phase III Randomized MELT Trial


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Advagraf, a once-daily extended-release tacrolimus formulation was released several years ago. Another once daily formulation of tacrolimus called LCPT, has now been developed. In this non-inferiority RCT, the LCPT formulation showed similar outcomes to standard twice-daily tacrolimus with a lower daily dose. The availability of multiple once-daily tacrolimus formulations, as well as several generic versions […]

No Comments Posted in Renal Transplantation
January 28, 2013

Conversion From Twice-Daily Tacrolimus to Once-Daily Extended Release Tacrolimus (LCPT): The Phase III Randomized MELT Trial


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Advagraf, a once-daily extended-release tacrolimus formulation was released several years ago. Another once daily formulation of tacrolimus called LCPT, has now been developed. In this non-inferiority RCT, the LCPT formulation showed similar outcomes to standard twice-daily tacrolimus with a lower daily dose. The availability of multiple once-daily tacrolimus formulations, as well as several generic versions […]

No Comments Posted in Renal Transplantation
February 23, 2012

Use of sublingual tacrolimus in lung transplant recipients


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Oral administration of tacrolimus in lung transplant recipients is preferred over intravenous administration for reasons of cost, side effects, and predictability of blood concentrations.  Sublingual tacrolimus has been used as an alternative to intravenous drug in patients when oral tacrolimus cannot be administered.  Using a retrospective analysis of a cohort of 34 lung transplant patients […]

No Comments Posted in Lung Transplantation
August 14, 2011

The ORION Study: Comparison of Two Sirolimus-Based Regimens versus Tacrolimus and Mycophenolate Mofetil in Renal Allograft Recipients


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This randomized controlled trial in de novo renal transplant recipients compared a standard immunosuppressive protocol of daclizumab induction, tacrolimus, mycophenolate mofetil (MMF) and steroids, to either: sirolimus and tacrolimus, with tacrolimus discontinued by four months post-transplant, or sirolimus and MMF. The sirolimus and MMF group was stopped early due to a high incidence of acute […]

No Comments Posted in Renal Transplantation
July 4, 2011

A prospective, randomized trial of single-drug versus dual-drug immunosuppression in heart transplantation: the tacrolimus in combination, tacrolimus alone compared (TICTAC) trial


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The TICTAC trial is the first prospective test of single-drug versus dual-drug maintenance immunosuppression in heart transplantation. Rapid steroid tapering was successful in all study patients. Three-year survival and low rates of allograft rejection and vasculopathy were observed in both arms (either TAC monotherapy or TAC/MMF), supporting the efficacy of either regimen along with a […]

No Comments Posted in Cardiac Transplantation