Posts Tagged ‘Ventricular Assist Device’

November 18, 2011

Effect of sensitization in US heart transplant recipients bridged with a ventricular assist device: Update in a modern cohort


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This study reviewed outcomes of 1544 UNOS based patients bridged to transplant with the HeartMate II or Thoratec XVE devices based on distribution of percentage panel reactive antibody levels.  Contrary to some previously published single center studies and smaller cohorts, highly sensitized patients bridged to transplant experienced excellent survival outcomes after orthotopic heart transplantation.

No Comments Posted in Cardiac Transplantation
October 1, 2011

Stable patients on left ventricular assist device support have a disproportionate advantage: Time to re-evaluate the current UNOS policy


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A recurrent theme at the annual International Society of Heart and Lung Transplant and the Heart Failure Society of America meetings is the need to consider further revision in the UNOS wait list criteria.  This paper reviews the justification and evolution of the current criteria through the era of mechanical circulatory support (MCS) and addresses […]

No Comments Posted in Cardiac Transplantation
October 1, 2011

The use of the HeartWare HVAD for long-term right ventricular support after implantation of the HeartMate II device


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The field of mechanical circulatory support continues to explore new avenues for providing patients with appropriate combinations of short and long-term support.  This case report reviews the simultaneous use of a rotary flow device and centrifugal device in a currently rare combination to provide what was eventually determined to be long-term biventricular destination therapy.

No Comments Posted in Cardiac Transplantation
August 14, 2011

Inhaled nitric oxide after left ventricular assist device implantation: A prospective, randomized, double-blind, multicenter, placebo-controlled trial


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The prophylactic use of inhaled nitric oxide (iNO) to reduce pulmonary vascular resistance (PVR), thereby reducing the likelihood or RV dysfunction is considered routine in many MCS and cardiac transplant centers. This study was a relatively large, prospective, randomized, controlled trial to assess the utility of the prophylactic use of iNO in preventing post-operative RVD […]

No Comments Posted in Cardiac Transplantation
July 4, 2011

Results of the post-U.S. Food and Drug Administration-approval study with a continuous flow left ventricular assist device as a bridge to heart transplantation: a prospective study using the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support)


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Outcomes for patients supported on mechanical circulatory support continue to improve.The results of this post-approval study support the original findings from the pivotal clinical trial regarding the efficacyand risk profile of the HM II LVAD in a post-marketapproval “real world” BTT (Bridge to Transplant) population.Trends in patient selection and outcome are described.  Favorable improvements in […]

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