August 14, 2011

The Impact of Pancreas Transplantation on Kidney Allograft Survival


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Pancreas-after-kidney (PAK) transplantation optimizes the use of living-donor kidneys and addresses the problems of both type I diabetes and end-stage renal disease. However, there are concerns about requiring patients to undergo two operations, as well as the impact that the more intense immunosuppression early post-pancreas transplant may have on renal allograft function. This registry study compares outcomes of type I diabetic patients who received a living-donor kidney transplant alone compared to those who received a PAK. Propensity-score analysis was used to minimize selection bias between the two groups. Long-term kidney allograft survival was better in the PAK group, even in patients with a lower level of renal function at the time of transplant.

 

Renal Transplantation

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