September 27, 2010

The Impact of Timing of Maximal Crystalloid Hydration on Early Graft Function During Kidney Transplantation


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Perioperative volume status and hypotension can lead to delayed graft function post-transplant. Mannitol and crystalloids are evidence-based strategies to reduce DGF rates, while furosemide and albumin have not been shown to decrease the risk. In this small, single-center blinded randomized controlled trial, a strategy of crystalloid administration to a target central venous pressure resulted in better intraoperative blood pressure, less use of pressors and furosemide and a faster fall in serum creatinine.  This study highlights the importance of perioperative fluid management on outcomes post-transplant.

Renal Transplantation