November 18, 2011

Treatment of Kidney Transplant Recipients With ACEi/ARB and Risk of Respiratory Tract Cancer: A Collaborative Transplant Study Report


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

Meta-analyses in the general population have suggested that ACE-inhibitors and angiotensin receptor blockers may increase the risk of cancer, particularly lung cancer. In this report from the international Collaborative Transplant Study, use of ACE-I or ARB as associated with a statistically significant increased risk of lung cancer, but only in patients with a smoking history. This was not a randomized controlled trial, and this study cannot determine whether the risks of ACE-I/ARB use in high-risk patients would outweigh their potential benefit.

Renal Transplantation

Tags: , , ,