February 23, 2012

Use of sublingual tacrolimus in lung transplant recipients


Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177

Warning: Invalid argument supplied for foreach() in /nfs/c04/h03/mnt/65750/domains/transplantnow.com/html/wp-content/themes/nephrology/scripts/pubmed.php on line 177
.   .   

Oral administration of tacrolimus in lung transplant recipients is preferred over intravenous administration for reasons of cost, side effects, and predictability of blood concentrations.  Sublingual tacrolimus has been used as an alternative to intravenous drug in patients when oral tacrolimus cannot be administered.  Using a retrospective analysis of a cohort of 34 lung transplant patients who had transitioned from either oral to sublingual tacrolimus, or from sublingual to oral tacrolimus, the authors of this paper calculated the sublingual-to-oral conversion ratio for tacrolimus.  A calculated ratio of 0.46 ± 0.20 indicates that sublingual tacrolimus administered at approximately half the oral dose achieves equal therapeutic blood concentrations.

Lung Transplantation

Tags: , ,