Archive for the ‘Pancreas Transplantation’ Category

January 28, 2013

Consensus Guidelines on the Testing and Clinical Management Issues Associated With HLA and Non-HLA Antibodies in Transplantation


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Solid phase assays on the Luminex platform have become the standard for the detection and characterization of HLA antibodies. However, transplant professionals have struggled with interpretation of the highly sensitive Luminex assay with respect to cytotoxicity assays and clinical relevance. To tackle this problem The Transplantation Society asked a group of experts with extensive experience […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
January 28, 2013

Effects of HLA-Matched Blood Transfusion for Patients Awaiting Renal Transplantation


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HLA sensitization in the pre-transplant period can limit the chances of successfully receiving a transplant. Sensitization (primarily to mismatched HLA class I) can occur as a result of blood transfusions due to the presence of platelets in each unit of blood and the small number of leukocytes that remain even in leuko-depleted blood. This study […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
January 28, 2013

Effects of HLA-Matched Blood Transfusion for Patients Awaiting Renal Transplantation


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Preventing the development of anti-HLA antibodies is an important step in improving access to transplantation. In this non-randomized retrospective study, patients who received red blood cell transfusions from donors who were closely matched for class I antigens were less likely to develop anti-HLA antibodies than patients who received randomly selected donors. These findings are intriguing, […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
January 28, 2013

Pancreas-After-Kidney Versus Synchronous Pancreas-Kidney Transplantation: Comparison of Intermediate-Term Results


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Most registries show worse outcomes with pancreas-after-kidney (PAK) compared to simultaneous pancreas-kidney (SPK) transplants. In this single-centre, retrospective study, living donor renal transplants followed by pancreas transplants showed comparable results to SPK, despite the long time between kidney and pancreas transplants. Greater use of PAK may shorten time of dialysis for patient with a living […]

No Comments Posted in Pancreas Transplantation, Renal Transplantation
October 30, 2012

Tobacco Smoking and Solid Organ Transplantation

Smoking remains a major public health issue. This review article discuss the effects of smoking by both donors and recipients on outcomes after transplant. It also covers the literature on smoking cessation. They also argue whether active smoking should be a contraindication to transplantation.

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
July 9, 2012

Arguments against promoting organ transplants from brain-dead donors, and views of contemporary Japanese on life and death


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A revision of Japan’s Organ Transplant Law in 2009 led to an ethical debate on the differences in definitions of death, age requirements for donors, requirements for brain-death determination and organ extraction, and the appropriateness of priority transplants for relatives. Many hoped the revised law would permit transplants in Japan according to global standards. However, […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
July 9, 2012

Organ donation and priority points in Israel: an ethical analysis


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In order to combat low rates of deceased donor donation, Israel has adopted an innovative program that gives potential recipients extra points if they or a relative have agreed to donate an organ. The authors argue the ethical merits and disadvantages of such a system, highlights issues of potential inequalities related to: (a) the number […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
July 9, 2012

Effect of an iPod video intervention on consent to donate organs: a randomized trial


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Racial disparities in intention to donate are well known. This randomized study showed a short iPod video to Ohio residents going to the DMV, and measured whether it increased organ donor designation on a license, permit, or identification card. The researchers found an increase in designations for both black and white participants. While there is […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
April 14, 2012

Nudge, nudge or shove, shove – the right way for nudges to increase the supply of donated cadaver organs


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This article advocates the use of “nudges” to increase the supply of donated organs.  A nudge is “any aspect of the choice architecture that alters people’s behavior in a predictable way without forbidding any options or significantly changing their economic incentives” eg. changing the sign on a waste receptacle from “waste” to “landfill” to encourage […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation
April 14, 2012

The dead donor rule and means-end reasoning–a reply to Gardiner and Sparrow


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Gardiner and Sparrow argued in a 2010 article that the pre-mortem procedures as typically used in donation after cardiac death (DCD) protocols violate a proper understanding of the dead donor rule (DDR). Napier argues that whether or not particular pre-mortem interventions violate this condition of respect for the donor will depend on whether they are […]

No Comments Posted in Cardiac Transplantation, Intestinal Transplantation, Liver Transplantation, Lung Transplantation, Pancreas Transplantation, Renal Transplantation