Archive for the ‘Transplant Infectious Disease’ Category

January 28, 2013

DAS181 treatment of severe parainfluenza type 3 pneumonia in a lung transplant recipient.


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Respiratory viral infections can cause severe pneumonia in lung transplant recipients as well are associated with acute rejection and long-term morbidity with bronchiolitis obliterans syndrome. There are no specific antiviral options for the majority of respiratory viruses. DAS181 is a novel sialidase fusion protein and is administered by inhalation. The authors describe the use of […]

No Comments Posted in Transplant Infectious Disease
January 28, 2013

Assessment of Cytomegalovirus-Specific Cell-Mediated Immunity for the Prediction of Cytomegalovirus Disease in High-Risk Solid-Organ Transplant Recipients: A Multicenter Cohort Study.


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Late CMV disease occurring after prophylaxis is a significant issue in CMV mismatched transplant recipients and predicting which patients will develop late CMV disease is difficult. In the last few years, immune monitoring has gained significant importance in the management of CMV. In this multicenter, prospective cohort study, the authors followed 127 D+/R- transplant patients […]

No Comments Posted in Transplant Infectious Disease
January 28, 2013

The Time Course of Development and Impact From Viral Resistance Against Ganciclovir in Cytomegalovirus Infection.


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The authors conducted a study of ganciclovir resistant mutations (GRM) of the UL97 gene in a cohort of 99 SOT recipients who were diagnosed with a first episode of CMV infection. GRMs were defined as ‘signature’ if the mutant/wildtype ganciclovir IC50 ratio was >2 and ‘polymorphic’ if this ratio was

No Comments Posted in Transplant Infectious Disease
January 28, 2013

Epidemiology, risk factors, and outcomes of Clostridium difficile infection in kidney transplant recipients.


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Clostridium difficile infections cause morbidity and mortality. The authors conducted a retrospective review of Clostridium difficile infection (CDI) in kidney transplant recipients at their center over a 3 year period. The overall rate of CDI was 6.1% and increased over time during the study. A case-control study was subsequently performed to determine the risk factors […]

No Comments Posted in Transplant Infectious Disease
January 28, 2013

Epidemiology, Clinical Characteristics and Outcomes of Extensively Drug-Resistant Acinetobacter baumannii Infections among Solid Organ Transplant Recipients.


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Acinetobacter is an important nosocomial pathogen. Extensively drug resistant Acinetobacter is generally only sensitive to colistin and tigecycline. The authors performed a retrospective study of SOT recipients over a 5 year period, that were colonized or infected with extensively drug resistant Acinetobacter to determine outcomes. 69 patients were included, most of whom had ventilator-associated pneumonia. […]

No Comments Posted in Transplant Infectious Disease
January 28, 2013

Increased incidence of cutaneous squamous cell carcinoma in lung transplant recipients taking long-term voriconazole


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Voriconazole is commonly prescribed for treatment of fungal infections in lung transplant recipients. Typically patients are treated for several weeks with this medication. This retrospective study of 120 lung transplant recipients compared the incidence of squamous cell carcinoma in patients with and without voriconazole use. Squamous cell carcinomas (SCC) developed in 39.5% of patients who […]

No Comments Posted in Lung Transplantation, Transplant Infectious Disease
January 28, 2013

Epidemiology, risk factors, and outcomes of Clostridium difficile infection in kidney transplant recipients.


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Clostridium difficile infections cause morbidity and mortality. The authors conducted a retrospective review of Clostridium difficile infection (CDI) in kidney transplant recipients at their center over a 3 year period. The overall rate of CDI was 6.1% and increased over time during the study. A case-control study was subsequently performed to determine the risk factors […]

No Comments Posted in Transplant Infectious Disease
January 28, 2013

DAS181 treatment of severe parainfluenza type 3 pneumonia in a lung transplant recipient.


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.   .   

Respiratory viral infections can cause severe pneumonia in lung transplant recipients as well are associated with acute rejection and long-term morbidity with bronchiolitis obliterans syndrome. There are no specific antiviral options for the majority of respiratory viruses. DAS181 is a novel sialidase fusion protein and is administered by inhalation. The authors describe the use of […]

No Comments Posted in Transplant Infectious Disease
January 28, 2013

Assessment of Cytomegalovirus-Specific Cell-Mediated Immunity for the Prediction of Cytomegalovirus Disease in High-Risk Solid-Organ Transplant Recipients: A Multicenter Cohort Study.


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Late CMV disease occurring after prophylaxis is a significant issue in CMV mismatched transplant recipients and predicting which patients will develop late CMV disease is difficult. In the last few years, immune monitoring has gained significant importance in the management of CMV. In this multicenter, prospective cohort study, the authors followed 127 D+/R- transplant patients […]

No Comments Posted in Transplant Infectious Disease
January 28, 2013

Epidemiology, Clinical Characteristics and Outcomes of Extensively Drug-Resistant Acinetobacter baumannii Infections among Solid Organ Transplant Recipients.


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.   .   

Acinetobacter is an important nosocomial pathogen. Extensively drug resistant Acinetobacter is generally only sensitive to colistin and tigecycline. The authors performed a retrospective study of SOT recipients over a 5 year period, that were colonized or infected with extensively drug resistant Acinetobacter to determine outcomes. 69 patients were included, most of whom had ventilator-associated pneumonia. […]

No Comments Posted in Transplant Infectious Disease