November 28, 2013
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Liver transplants rarely experience antibody-mediated rejection, and it has been suggested that a liver transplant can protect the kidney if a simultaneous transplant is performed. In this single-center study, patients who received a simultaneous liver-kidney transplant had a higher risk of acute rejection, but similar renal function and patient and graft survival, whether or not […]
November 28, 2013
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Although testing for HLA antibodies is long-established practice in transplantation, the immune system actually makes antibodies against specific epitopes, not antigens. This study used the HLA Matchmaker program to assess whether the degree of epitope mismatching predicted the development of post-transplant class II donor-specific antibodies. Thresholds for epitope mismatching at DR and DQ were found. […]
September 26, 2013
Antibody-mediated pancreas transplant rejection is a relatively recently recognized entity. In this retrospective study, the rate of antibody-mediated rejection post-pancreas transplant was similar to that of acute cellular rejection. Class I DSA were more predictive of antibody-mediated rejection than class II DSA. Antibody-mediated rejection should be considered in all patients with pancreas graft dysfunction post-transplant.
June 21, 2013
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Approximately 10 – 20% of heart transplant recipients will develop AMR. Standardized nomenclature has improved the diagnosis. This single center study revisits the risks of Class I and II DSA to C4D +IF and graft failure. C4d staining correlated better with graft failure in patients with DSA to only Class I or DSA to both […]
April 1, 2013
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This preliminary study from Mayo clinic demonstrated that cardiac transplant patients with preformed class II DSA may be at increased risk for accelerated graft vasculopathy on consecutive 3D IVUS. Although this technology may not be available at all centers, this sstudy provides further weight to the potential clinical impact of class II DSA.
January 28, 2013
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Solid phase assays on the Luminex platform have become the standard for the detection and characterization of HLA antibodies. However, transplant professionals have struggled with interpretation of the highly sensitive Luminex assay with respect to cytotoxicity assays and clinical relevance. To tackle this problem The Transplantation Society asked a group of experts with extensive experience […]
January 28, 2013
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Solid phase assays on the Luminex platform have become the standard for the detection and characterization of HLA antibodies. However, transplant professionals have struggled with interpretation of the highly sensitive Luminex assay with respect to cytotoxicity assays and clinical relevance. To tackle this problem The Transplantation Society asked a group of experts with extensive experience […]
July 4, 2011
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Although simultaneous liver and kidney transplantation (SLKT) is uncommon, the liver’s ability to resist hyperacute antibody mediated rejection (AbMR) may allow the transplant to succeed despite the presence of pre-existing donor specific antibody (DSA). However, the long term impact of pre-existing DSA in SLKT is incompletely understood. This study analyzed a small cohort of SLKT […]
July 4, 2011
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Antibody-mediated rejection (AbMR) requires the production of donor specific antibody (DSA) by recipient plasma cells and can present at early or late times post-transplant. Bortezomib is a proteasome inhibitor (PI) approved by the FDA for treatment of multiple myeloma that is increasingly being used off-label for the treatment of AbMR. This study, from one of […]
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